J. Cell. Physiol. 2007, 212, 60-67.

d-, but not m-, opioid receptor stabilizes K⁺ homeostasis by reducing Ca²⁺ influx in the cortex during acute hypoxia.

Chao, D.; Bazzy-Asaad, A.; Balboni, G.; Xia, Y.

 

Bioorganic & Medicinal Chemistry 2007, 15, 3143-3151.

Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.

Balboni, G.; Onnis, V.; Congiu, C.; Zotti, M.; Sasaki, Y.; Ambo, A..; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.; Lazzari, I.; Trapella, C.; Salvadori, S.

 

Peptides 2006, 27, 3322-3330.

Dmt-Tic-NH-CH₂-Bid (UFP-502), a Potent DOP Receptor agonist: In Vitro and in Vivo Studies.

Vergura, R.; Valenti, E.; Hebbes, C. P.; Gavioli, E. C.; Spagnolo, B.; McDonald, J.; Lambert, D. G.; Balboni, G.; Salvadori, S.; Regoli, D.; Calò, G.

 

Journal of Medicinal Chemistry 2006, 49, 5640-5643.

New Opioid Designed Multiple Ligand from Dmt-Tic and Morphinan Pharmacophores.

Neumeyer, J. L.; Peng, X.; Knapp, B. I.; Bidlack, J. M.; Lazarus, L. H.; Salvadori, S.; Trapella, C.; Balboni, G.

 

J. Med. Chem. 2006, 49, 5610-5617.

Effect of Lysine at C-Terminus of the Dmt-Tic Opioid Pharmacophore.

Balboni, G.; Onnis, V.; Congiu, C.; Zotti, M.; Sasaki, Y.; Ambo A.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.; Trapella, C.; Salvadori, S.

 

J. Med. Chem. 2006, 49, 3990-3993.

New 2’,6’-Dimethyl-L-tyrosine (Dmt) Opioid Peptidomimetics Based on the Aba-Gly Scaffold. Development of Unique m-Opioid receptor Ligands.

Ballet, S.; Salvadori, S.; Trapella, C.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.; Negri, L.; Giannini, E.; Lattanzi, R.; Tourwé, D.; Balboni, G.

 

J. Med. Chem. 2006; 49: 3653-3658.

6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in d- and m-Selective Opioid Peptides.

Vázquez, M. E.; Blanco, J. B.; Salvadori, S.; Trapella, C.; Argazzi, R.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.; Negri, L.; Giannini E.; Lattanzi, R.; Colucci, M.; Balboni, G.

 

Chem. Res. Chinese U. 2006, 22(2), 258-262.

Dimethyltyrosine, the Viagra of Opioids.

Lazarus, L. H.; Bryant, S. D.; Salvadori, S.; Guerrini, R.; Balboni, G.; Tsuda, Y.; Okada, Y.

 

Brain Researh 2006 Jan 19;1069(1):172-81.

Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats.

Torregrossa MM, Jutkiewicz EM, Mosberg HI, Balboni G, Watson SJ, Woods JH.

 

J Med Chem. 2005 Dec 29;48(26):8112-4.

Conversion of the potent d-opioid agonist H-Dmt-Tic-NH-CH₂-Bid into d-opioid antagonists by N¹-Benzimidazole alkylation.

Balboni G, Guerrini R, Salvadori S, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH.

 

J Med Chem. 2005 Aug 25;48(17):5608-5611.

From the Potent and Selective mu Opioid Receptor Agonist H-Dmt-D-Arg-Phe-Lys-NH₂ to the Potent delta Antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.

Balboni G, Cocco M T, Salvadori S, Romagnoli R., Sasaki Y, Okada Y, Bryant S D, Jinsmaa Y, Lazarus L H.

 

J Med Chem. 2004 Dec 16;47(26):6541-6546.

Highly Selective Fluorescent Analogue of the Potent delta-Opioid Receptor Antagonist Dmt-Tic.

Balboni G, Salvadori S, Dal Piaz A, Bortolotti F, Argazzi R, Negri L, Lattanzi R, Bryant SD, Jinsmaa Y, Lazarus LH.

 

Synthesis 2004, No. 18, pp. 3011-3016.

Synthesis of N^a-FmocN,N’-bis-Boc-5-,6- and 8-guanyl-1,2,3,4-tatrahydroisoquinoline-3-carboxylic Acid (5-GTIC and 8-GTIC

Severino B, Santagada V, Frecentese F, Perissutti E, Terracciano S, Fiorino F, Cirillo D, Salvadori S, Balboni G, Caliendo G.

 

J Med Chem. 2004 Jul 29;47(16):4066-71.

Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH.

 

Bioorg Med Chem. 2003 Dec 1;11(24):5435-41.

Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH.

 

J Med Chem. 2002 Dec 5;45(25):5556-63.

Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Jinsmaa Y, Bryant SD, Lazarus LH.

 

J Med Chem. 2002 Dec 5;45(25):5506-13.

Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.

Bryant SD, George C, Flippen-Anderson JL, Deschamps JR, Salvadori S, Balboni G, Guerrini R, Lazarus LH.

 

J Med Chem. 2002 Jan 31;45(3):713-20.

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.

Balboni G, Guerrini R, Salvadori S, Bianchi C, Rizzi D, Bryant SD, Lazarus LH.

 

J Med Chem. 2001 Aug 2;44(16):2536-43.

Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.

Baraldi PG, Balboni G, Pavani MG, Spalluto G, Tabrizi MA, Clercq ED, Balzarini J, Bando T, Sugiyama H, Romagnoli R.

 

Brain Res. 2001 May 25;902(1):131-4.

Inhibition of human multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist.

Lovekamp T, Cooper PS, Hardison J, Bryant SD, Guerrini R, Balboni G, Salvadori S, Lazarus LH.

 

Eur J Med Chem. 2000 Nov;35(11):979-88.

Synthesis and activity of 3-pyridylamine ligands at central nicotinic receptors.

Balboni G, Marastoni M, Merighi S, Andrea Borea P, Tomatis R.

 

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2745-8.

Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.

Santagada V, Balboni G, Caliendo G, Guerrini R, Salvadori S, Bianchi C, Bryant SD, Lazarus LH.

 

Peptides. 2000 Nov;21(11):1663-71.

Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei.

Balboni G, Salvadori S, Guerrini R, Bianchi C, Santagada V, Calliendo G, Bryant SD, Lazarus LH.

 

Eur J Pharmacol. 2000 Oct 6;406(1):R1-3.

Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.

Labarre M, Butterworth J, St-Onge S, Payza K, Schmidhammer H, Salvadori S, Balboni G, Guerrini R, Bryant SD, Lazarus LH.

 

Arzneimittelforschung. 2000 Jun;50(6):507-11.

Synthesis and binding of 3-aminopyridine derivatives at central nicotinic receptors.

Balboni G, Marastoni M, Merighi S, Borea PA, Tomatis R.

 

Neuroreport. 2000 Jul 14;11(10):2083-6.

Characterization of N,N(Me)2-Dmt-Tic-OH, a delta selective opioid dipeptide antagonist.

Monory K, Bryant SD, Kertesz I, Balboni G, Guerrini R, Toth G, Salvadori S, Lazarus LH, Borsodi A.

 

Biopolymers. 2000 Feb;53(2):213-9.

Effect of lysine residues on the deamidation reaction of asparagine side chains.

Capasso S, Balboni G, Di Cerbo P.

 

J Med Chem. 1999 Dec 16;42(25):5131-41.

Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.

Baraldi PG, Balboni G, Cacciari B, Guiotto A, Manfredini S, Romagnoli R, Spalluto G, Thurston DE, Howard PW, Bianchi N, Rutigliano C, Mischiati C, Gambari R.